The No is that Bethesda doesn't make their games for the Mac OS. (You have no idea how annoyed this makes me. I would love to play and mod the last two Fallout games easily, but alas I've not set myself up probably to do that on my Mac.)
The 'sort of' is that it is possible to install Widows on your Mac computer, and use your installed version of Windows to run software only meant for Windows.
Frankly, I'm not smart enough to walk you through this, maybe someone else will be, but if you have a licence for Windows, you can install the Windows OS on your computer in a few different ways.
You can probably do some googling to find out how, or you can hit up a tech savvy friend to walk you through it.
I haven't done this yet, since I haven't had the time since I got my Mac in the summer, but I plan on buying a friend a case of beer and giving them my Windows liscence key and asking them to dual boot my Mac so I can play the old Elder Scrolls games and Fallout New Vegas. (If you like Oblivion, You should try the Fallout games.) [ Razhie's advice column | Ask Razhie A Question ]
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