"Tweaker is a slang term for someone who abuses Methamphetamine, Cocaine or other stimulants. The term comes from tinkering behaviors associated with methamphetamine use. For example, taking apart a bicycle or stereo while under the influence of methamphetamines would be phrased 'tweaking on a bicycle or stereo'. Tweaking denotes a compulsive behavior. See also: insult" [ Mackenzie's advice column | Ask Mackenzie A Question ]
DangerNerd answered Friday July 22 2005, 2:23 am: Tweaker is a slang term for someone who uses drugs. Specifically crystal meth/crank/whatever they call it where you live.
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