Other than these circumstances, being itchy or irritated is something that needs to be checked out. You could have a sensitivity to the type of protection you're using (if you're having sex with a guy, there are vagina-friendly condom options) or (with guy or girl) you might be sensitive to hand lotion, etc.
It's best to see your gyno - you should have one if you are having sex - and explain what you're experiencing. She/he will be able to figure out what's going on and what you can do about it.
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